Hosted DNA language models: promoter, splice, enhancer, chromatin, expression, annotation
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https://mcp.genomicintelligence.ai/mcp15 Tools · 421 mslist_modelsList available models for a task.
Use to discover model ids before passing one as the `model`
argument to a predict tool. The same catalog is also available
as the resource `gi://models`.
Returns a FLAT object — {task, default_model, models: [...]} — not the
{data, meta} envelope the predict…List available models for a task. Use to discover model ids before passing one as the `model` argument to a predict tool. The same catalog is also available as the resource `gi://models`. Returns a FLAT object — {task, default_model, models: [...]} — not the {data, meta} envelope the predict…
| Parameter | Typ | Beschreibung |
|---|---|---|
| task* | string | Task name. One of: promoter, splice, enhancer, chromatin, expression, annotation. |
fetch_ensembl_sequenceFetch a gene's reference sequence from Ensembl and store it.
Returns a handle ({ref, name, length, preview, ...}). Pass the
`ref` to predict_* tools — the bases stay server-side. For
expression, use fetch_gene_for_expression instead (it prepares
the TSS-centred window that model needs).Fetch a gene's reference sequence from Ensembl and store it. Returns a handle ({ref, name, length, preview, ...}). Pass the `ref` to predict_* tools — the bases stay server-side. For expression, use fetch_gene_for_expression instead (it prepares the TSS-centred window that model needs).
| Parameter | Typ | Beschreibung |
|---|---|---|
| gene* | string | Gene symbol (e.g. 'TP53') or Ensembl ID. |
| species | string | Species name, e.g. 'human', 'mouse'. |
| flank_bp | integer | Extra bp added on each side of the gene body. |
fetch_regionFetch a genomic region by coordinates from Ensembl and store it.
For "find the genes in chr8:127,680,000-127,800,000"-style requests:
resolves a coordinate range to reference sequence and returns a handle
({ref, name, length, ...}) to pass to find_genes / predict_* — the bases
stay server-side…Fetch a genomic region by coordinates from Ensembl and store it. For "find the genes in chr8:127,680,000-127,800,000"-style requests: resolves a coordinate range to reference sequence and returns a handle ({ref, name, length, ...}) to pass to find_genes / predict_* — the bases stay server-side…
| Parameter | Typ | Beschreibung |
|---|---|---|
| region* | string | Genomic coordinates, e.g. 'chr8:127,680,000-127,800,000'. Commas, en/em dashes and '..' are accepted; the 'chr' prefix is optional. |
| species | string | Species name, e.g. 'human', 'mouse'. |
| strand | integer | 1 = plus (default), -1 = minus. find_genes (gene finding) is plus-oriented — keep 1 for annotation; use -1 only for a strand-sensitive task on a known minus-st… |
| flank_bp | integer | Extra bp added on each side of the region. |
fetch_gene_for_expressionFetch a gene's sequence prepared for expression prediction.
Resolves the gene's TSS via Ensembl and returns the exact
TSS-centred 9,198 bp window the expression model scores, as a handle
to pass to predict_expression(sequence_ref=...). Because the window is
exactly 9,198 bp, no `tss_index` is…Fetch a gene's sequence prepared for expression prediction. Resolves the gene's TSS via Ensembl and returns the exact TSS-centred 9,198 bp window the expression model scores, as a handle to pass to predict_expression(sequence_ref=...). Because the window is exactly 9,198 bp, no `tss_index` is…
| Parameter | Typ | Beschreibung |
|---|---|---|
| gene* | string | Gene symbol (e.g. 'HBB'). |
| species | string | Species name. |
load_demo_sequenceLoad a bundled demo reference sequence and return a handle.
The server ships one curated, task-correct positive control per task
(list them via the gi://sequences resource) — e.g.
`expression_hbb_k562` is a ready-to-use K562 expression window for
predict_expression. Stores the demo and returns…Load a bundled demo reference sequence and return a handle. The server ships one curated, task-correct positive control per task (list them via the gi://sequences resource) — e.g. `expression_hbb_k562` is a ready-to-use K562 expression window for predict_expression. Stores the demo and returns…
| Parameter | Typ | Beschreibung |
|---|---|---|
| name* | string | Demo name from gi://sequences, e.g. 'expression_hbb_k562', 'promoter_tp53', or 'annotation_hbb_chr11'. A gene token like 'TP53' also resolves. |
store_inline_sequenceStore a human-pasted sequence and return a handle to re-use it.
For a sequence you've already pasted into the conversation, this
gives back a short handle so you can run several tasks on it
without re-pasting the bases in each predict_* call. Note that the
full sequence still passes through th…Store a human-pasted sequence and return a handle to re-use it. For a sequence you've already pasted into the conversation, this gives back a short handle so you can run several tasks on it without re-pasting the bases in each predict_* call. Note that the full sequence still passes through th…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence* | string | DNA bases to store and get a handle for. Line breaks are fine — whitespace is stripped, so the handle holds bases. |
| name | string | Label for this sequence. |
predict_promoterPredict promoter regions (G0). 300–500,000 bp.
Returns the {data, meta} envelope: data.regions lists predicted
promoters with start/end/score.
300 bp is the task floor for every promoter model. The default
g0-promoter-2000bp scans a 2,000 bp context window, so a shorter
(but ≥300 bp) sequenc…Predict promoter regions (G0). 300–500,000 bp. Returns the {data, meta} envelope: data.regions lists predicted promoters with start/end/score. 300 bp is the task floor for every promoter model. The default g0-promoter-2000bp scans a 2,000 bp context window, so a shorter (but ≥300 bp) sequenc…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
predict_splicePredict splice donor/acceptor sites (G0 BigBird). 100–500,000 bp.
The model reads a 15,000 bp context window, so anything shorter is
scored against a padded window — feed a whole transcript locus when you
can. It is also strand-specific, and the wrong strand fails silently and
plausibly — it r…Predict splice donor/acceptor sites (G0 BigBird). 100–500,000 bp. The model reads a 15,000 bp context window, so anything shorter is scored against a padded window — feed a whole transcript locus when you can. It is also strand-specific, and the wrong strand fails silently and plausibly — it r…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
predict_enhancerPredict enhancer activity (G0 DeepSTARR). 50–500,000 bp.
50 bp is the task's admission floor (the API 422s below it), not a
statement about what the model reads: enhancer models score a 249 bp
context window, so 50–248 bp is accepted and scored against a padded
window. For a meaningful call, s…Predict enhancer activity (G0 DeepSTARR). 50–500,000 bp. 50 bp is the task's admission floor (the API 422s below it), not a statement about what the model reads: enhancer models score a 249 bp context window, so 50–248 bp is accepted and scored against a padded window. For a meaningful call, s…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
predict_chromatinChromatin annotation across 919 features (G0 DeepSEA). 200–500,000 bp.
The model reads a 1,000 bp context window; 200–999 bp is accepted and
scored against a padded window.Chromatin annotation across 919 features (G0 DeepSEA). 200–500,000 bp. The model reads a 1,000 bp context window; 200–999 bp is accepted and scored against a padded window.
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
predict_expressionPredict a gene's expression from a TSS-centred window.
Expression is cell-type-specific, so `description` (cell type /
assay context, e.g. 'K562 cell line') is REQUIRED — the API
rejects requests without it.
The model scores exactly 9,198 bp centred on the TSS (±4,599). Two
ways to supply th…Predict a gene's expression from a TSS-centred window. Expression is cell-type-specific, so `description` (cell type / assay context, e.g. 'K562 cell line') is REQUIRED — the API rejects requests without it. The model scores exactly 9,198 bp centred on the TSS (±4,599). Two ways to supply th…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| description | — | REQUIRED experimental context — cell type / assay / conditions (e.g. 'K562 cell line', 'liver tissue'). Expression is cell-type-specific; the API rejects reque… |
| tss_index | — | 0-based offset of the transcription start site into the sequence, counted in bases (whitespace is ignored). Required unless the sequence is exactly 9,198 bp; m… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
find_genesFind genes (transcript intervals) in a genomic region (async, ~8-25s).
Takes 1,000–500,000 bp. The floor is the strictest of the scanning
tasks: gene finding needs a region, not a site. (Only expression's
9,198 bp is higher, and that is a fixed window rather than a minimum
region size.)
Gene…Find genes (transcript intervals) in a genomic region (async, ~8-25s). Takes 1,000–500,000 bp. The floor is the strictest of the scanning tasks: gene finding needs a region, not a site. (Only expression's 9,198 bp is higher, and that is a fixed window rather than a minimum region size.) Gene…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases A/C/G/T/N (case-insensitive). Line breaks are ignored (a wrapped FASTA body may be pasted verbatim; a `>` header line may not). Mutually exclusive wi… |
| sequence_ref | — | Handle (seq_…) from any acquisition tool (fetch_ensembl_sequence, fetch_region, fetch_gene_for_expression, load_demo_sequence, load_local_fasta, store_inline_s… |
| sequence_name | string | Label echoed back in the response (ignored when `sequence_ref` is used). |
| model | — | Optional model id; omit for the task default. See list_models. |
| wait | boolean | Default True: block and stream progress until the result is ready. Set False for detached mode — returns a job_id immediately to poll with get_job. |
find_genes_and_predict_expressionFind genes in a sequence, then predict each gene's expression (composite).
Server-side chaining in ONE call: finds genes (transcript intervals,
with their TSS) in the sequence, then predicts expression off each
discovered TSS in the given experimental context. This is the right
tool whenever y…Find genes in a sequence, then predict each gene's expression (composite). Server-side chaining in ONE call: finds genes (transcript intervals, with their TSS) in the sequence, then predicts expression off each discovered TSS in the given experimental context. This is the right tool whenever y…
| Parameter | Typ | Beschreibung |
|---|---|---|
| sequence | — | DNA bases, 1,000-500,000 bp (line breaks ignored). Mutually exclusive with sequence_ref. |
| sequence_ref | — | Stored sequence handle. Mutually exclusive with sequence. |
| description | — | REQUIRED experimental context — cell type / assay / conditions (e.g. 'K562 cell line'), applied to every found gene. The workflow ends in expression, which the… |
| sequence_name | string | Label echoed back. |
| wait | boolean | Default True: block and stream progress until the result is ready. Set False for detached mode — returns a job_id immediately to poll with get_job. |
get_jobPoll an async job once.
Returns the {data, meta} result if complete, a progress envelope
if still running, or an error envelope if it failed.Poll an async job once. Returns the {data, meta} result if complete, a progress envelope if still running, or an error envelope if it failed.
| Parameter | Typ | Beschreibung |
|---|---|---|
| job_id* | string | Job id from an async tool (find_genes, find_genes_and_predict_expression). |
list_jobsList the caller's recent async jobs (also available as gi://jobs/recent).List the caller's recent async jobs (also available as gi://jobs/recent).
| Parameter | Typ | Beschreibung |
|---|---|---|
| limit | integer | Max number of recent jobs to return. |
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Hosted DNA language models: promoter, splice, enhancer, chromatin, expression, annotation
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